When LDN has combination with chemotherapy, it enhances inhibition of tumor formation. This finding provides new insights into the pathogenesis and treatment of ovarian keto kreme cancer. Among the U.S. women, ovarian cancer is the fourth leading cause of death in cancer-related mortality.

This study aims to demonstrate that, through the LDN adjusts the opioid growth factor (OGF) – opioid growth factor receptor (OGFr) axis, whether the eggs of the tumors progress docetaxel which has been diagnosed will be changed or not. In addition, the researchers wanted to find out if LDN can be combined with standard chemotherapy of ovarian cancer and play a greater role. If we establish an LDN model, q hydroxyl dihydroxyvitamin yards brown ketone (NTX) exposures for six hours every 2 days, it can be found that the DNA synthesis and cell replication reduced. When the NTX short-term exposure is combined with standard chemotherapy drugs (paclitaxel or cisplatin), it can be observed that enhance of anti-cancer effects has no relations with any drink ketones challenge drugs. It is not paclitaxel or cisplatin, but the effects of LDN can be reversed. It indicates that LDN is non-toxic.

The LDN alone or LDN associated with chemotherapy drugs are shown to be effective. But whether the LDN tumor transplanted is suitable mice is still not clear. Use human ovarian cancer xenografts in nude mice, the LDN inhibition of tumor progression are found. It reduces DNA synthesis and angiogenesis, but does not change the cell survival. The LDN inhibitory effect on cancer progression can be comparable to cisplatin or paclitaxel. However, LDN combining with cisplatin, but not paclitaxel, has better anti-tumor effect than LDN alone or paclitaxel. In addition, cisplatin toxic to mice can make weight loss. However, the LDN in combination with cisplatin will reduce the toxicity of cisplatin irinotecan.It suggests that the protective effect of LDN on the adverse events is caused by the chemotherapy drugs. Finally, it is found that LDN can upregulate the expression of OGF and OGFr, indicating that LDN can activate this endogenous opioid system and thus inhibiting cell proliferation.